相关实验视频

Updated: Jul 17, 2025

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

Published on: November 6, 2020

坎迪达诱导的颗粒细胞髓质衍生抑制细胞对多微生物败血症有保护作用

Shannon Esher Righi¹, Amanda J Harriett¹, Elizabeth A Lilly¹

¹Department of Microbiology and Immunology, Tulane University School of Medicine , New Orleans, Louisiana, USA.

|September 8, 2023

概括

用Candida物种进行免疫接种训练了髓质衍生抑制细胞 (MDSCs),以防止致命的败血症. 这些MDSC通过IN-10 (IL-10) 减少炎症,提供潜在的败血症治疗.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
细胞生物学细胞生物学

背景情况:

由于复杂的炎症反应,多微生物腹腔内感染会导致危及生命的败血症.
现有的败血症治疗方法受到其动态炎症性质的挑战.
之前的研究表明,用低毒性的Candida物种进行免疫接种可以保护小鼠免受败血症的侵害.

研究的目的:

在Candida免疫接种后,确定免疫细胞的特征,以调解对抗多微生物败血症的保护.
阐明这些细胞赋予保护的机制,重点关注炎症控制.
探索特定细胞因子,如IL-10在这种保护性反应中的作用.

主要方法:

给小鼠接种了低毒性Candida物种的免疫.
随后的挑战是致命的多微生物败血症模型.
Gr-1+多态核白细胞 (PMNs) 的表征及其功能分析,包括细胞因子分析 (IL-10).

主要成果:

保护性Gr-1+ PMN被确定为由髓质衍生抑制细胞 (MDSCs).
MDSCs通过在败血症期间废除致命炎症来调解保护.
发现抗炎性细胞因子介素-10 (IL-10) 对MDSCs的保护作用至关重要.

结论:

训练有素的MDSC在控制败血症急性致死性炎症方面发挥着至关重要的作用.
由MDSCs产生的IL-10是败血症保护的关键媒介.
这些发现支持了为临床败血症治疗训练耐受性免疫反应的潜力.

关键词:

这是一种Candida Candida.来自骨髓细胞的抑制细胞.多微生物性败血症训练有素的天生的免疫力.

更多相关视频

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS

Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS

Published on: June 18, 2012

相关概念视频

Differentiation of Common Myeloid Progenitor Cells

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

Defense Against Bacterial Pathogens

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...