PFKFB3驱动的血管光滑肌细胞糖解通过改变的FoxO3和乳酸盐生产促进血管化

相关实验视频

Updated: Jul 17, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.6K

Jiaxin Chen1, Hongjiao Yu2, Xiao Tan1

  • 1Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, the Second Affiliated Hospital, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|September 8, 2023
PubMed
概括

阻断酶6-果糖-2-激酶/果糖-2,6-双酸酶3 (PFKFB3) 的作用降低了糖解,并抑制了血管化. 这一发现揭示了PFKFB3作为治疗血管化的潜在治疗标.

关键词:
PFKFB3B3 是一个很好的选择.葡萄糖溶解是什么骨质性转基因差异化的转基因.血管化 血管化

更多相关视频

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models09:01

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Published on: January 27, 2023

1.7K
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.0K

相关概念视频

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K