在实验性模型中,Nesfatin-1通过减少氧化应激来发挥抗作用
Seval Musuroglu Keloglan1, Fatma Banu Aycik2, Suleyman Emre Kocacan2
1Department of Physiology, Faculty of Medicine, University of Adiyaman, Adiyaman, Turkey.
Acta neurobiologiae experimentalis
|September 8, 2023
概括
纳斯法-1通过在老鼠模型中减少发作频率来表现出抗发作性质. 这种神经是一种神经.
科学领域:
- 神经科学和药理学 神经科学和药理学
- 的研究研究.
- 神经的功能 神经的功能
背景情况:
- 神经与病的发病有关.
- 涅斯法-1是一种神经,其在中的作用需要进一步研究.
- 在老鼠中,青素诱导的发作为研究抗机制提供了一个模型.
研究的目的:
- 在青素诱导的模型中研究内沙丁-1的抗作用.
- 探索氧化应激对内沙丁-1抗活性的影响.
- 评估nesfatin-1和皮质otropin释放因子 (CRF) 途径之间的相互作用.
主要方法:
- 在56只白色Wistar大鼠中,使用青素诱导了型活动.
- 纳斯法-1是通过脑内静脉管内 (ICV) 给药的. 在不同的剂量.
- 分析了氧化应激标志物 (SOD,GSH,GPx,GR,MDA) 的大脑水平.
主要成果:
- 纳斯法廷-1 (25,50,100 pmol) 显著降低了发作的频率,但并没有降低幅.
- 纳斯法-1增加了谷氨过氧化酶 (GPx) 和谷氨减少酶 (GR) 的水平.
- 纳斯法廷-1 (50 pmol) 降低了甲 (MDA) 水平,这表明氧化应激减少.
结论:
- 在青素诱导的模型中,纳斯法丁-1 显示出显著的抗作用.
- 尼斯法-1的抗作用似乎是通过调节氧化应激来调节的.
- 皮质otropin释放因子 (CRF) 受体对抗性没有影响nesfatin-1的疗效.
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