循环节错位改变了轮换轮班工人突出网络的静止状态功能连接
Sun-Young Kim1, Kyung Hwa Lee2,3, Ha Young Lee3
1Department of Psychiatry, Ewha Womans University College of Medicine, Ewha Womans University Seoul Hospital, Seoul, Republic of Korea.
Sleep
|September 8, 2023
概括
轮班工作者在突出网络中表现出功能性大脑连接的改变,这可能会随着时间的推移影响注意力和突出检测,尽管睡眠或认知没有立即的缺陷.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 睡眠医学 睡眠医学
背景情况:
- 轮班工作扰乱昼夜节律,并与各种健康问题有关.
- 突出网络 (SN) 在检测和定位相关刺激方面发挥着至关重要的作用.
- 了解轮班工人SN功能连接 (rsFC) 对于评估认知和情绪调节至关重要.
研究的目的:
- 为了比较旋转轮班工人 (RSW) 和控制器之间的突出网络 (SN) 的静止状态功能连接 (rsFC).
- 在RSW中调查SN rsFC与睡眠,情绪,认知和注意力之间的相关性.
主要方法:
- 60名RSW和57名对照人接受了休息状态的fMRI,结构性MRI和睡眠评估 (问卷,多睡眠学,动作学).
- 用前带皮质 (ACC) 和前半岛 (AI) 作为种子进行了基于种子的RSFC分析.
- 进行了AI和ACC rsFC的组比较,以及相关性分析.
主要成果:
- RSWs显示ACC右侧insula rsFC减少和ACC rsFC增加与左叶和右上额头/补充运动区域 (SFG/SMA).
- 此外,RSW还表现出右AI-右上顶叶 (SPL) rsFC的减少.
- ACC-AI rsFC与24小时休息活动节律性相关.
结论:
- 尽管没有明显的睡眠障碍或认知缺陷,但RSW中改变的SN rsFC表明了突出检测和注意力控制的潜在长期损害.
- 这些发现凸显了轮班工作对大脑功能的微妙神经后果.
- 需要进一步的研究来了解这些连接变化的长期影响.
相关概念视频
02:19Circadian Rhythms and Gene Regulation
4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
02:45Biological Clocks and Seasonal Responses
34.7K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
34.7K
01:13Functional Brain Systems: Reticular Formation
2.0K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
2.0K