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对影响胚胎转移以进行体外受精后怀孕率的方法因素的大规模回顾性分析

Mustecep Kavrut¹, Fulya Gokdagli Sagir², Zafer Atayurt³

¹Private Center, Fulya Academy, Istanbul Turkey.

|September 8, 2023

概括

年龄较小,转移的胚胎更多,转移深度更大,冷胚胎转移 (FET) 和植入前遗传检测显著增加了体外受精中的怀孕率. 这些因素优化了生育治疗的成功.

科学领域:

生殖医学生殖医学
在体外受精过程中受精.
胚胎移植技术胚胎移植技术

背景情况:

试管婴儿 (IVF) 成功率受到各种程序和患者特定因素的影响.
优化胚胎移植 (ET) 协议对于改善妊娠结果至关重要.

研究的目的:

调查方法因素对IVF胚胎移植 (ET) 后怀孕率的影响.
确定影响ET后成功怀孕的关键变量.

主要方法:

对2048名接受超声波导向第一次冷胚胎移植 (FET) 或新鲜ET的患者进行了回顾性横截面研究.
分析了包括患者年龄,ET协议 (冷与新鲜),植入前遗传测试 (PGT),移植胚胎数量 (NET) 和胚胎底部距离在内的因素.
多重回归分析以确定每个因素对怀孕率的统计意义.

主要成果:

年轻患者的怀孕率明显高 (平均年龄为31.51岁而不是35.34岁).
与更高怀孕概率积极相关的因素包括:年龄较小,较高的NET,较大的胚胎底部距离,FET和PGT.
对年龄,NET,胚胎底部距离和FET观察到统计学意义 (P < .001);PGT也显示出意义 (P = .012).

结论:

年龄较小,转移胚胎数量增加,胚胎底部距离较大,冷胚胎转移和植入前遗传检测与更高的怀孕率有关.
这些发现表明,优化这些方法因素可以提高试管婴儿的成功.
在选择最佳的ET协议时,考虑到偏好,成本和时间的个性化患者护理仍然是必不可少的.

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