在儿科心肺绕道术期间的指数化氧气输送是术后急性损伤的可修改风险因素
Molly Dreher1, Jungwon Min2, Constantine Mavroudis3
1Department of Cardiovascular Perfusion, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
The journal of extra-corporeal technology
|September 8, 2023
概括
在心肺旁路术期间保持足够的索引氧气输送可能会减少儿科患者急性损伤. 新生儿和婴儿的特定门显示出预防心脏手术后这种并发症的潜力.
科学领域:
- 儿科心脏手术 儿科心脏手术
- 腎臟病學 (nephrology) 是一種醫學.
- 心血管外科心血管外科
背景情况:
- 急性损伤 (AKI) 是小儿心脏手术后的常见并发症.
- 在这个人群中,已经确定了AKI的少数可修改的风险因素.
- 这项研究调查了心肺绕道术期间索引氧气输送与术后AKI之间的关联.
研究的目的:
- 为了确定心肺旁路术期间的索引氧气输送是否与儿科患者的术后急性损伤有关.
- 确定指数化氧气输送的特定值,从而预测AKI风险.
主要方法:
- 对980名儿童患者 (<1岁) 进行心肺旁路心脏手术 (2013-2020年) 的回顾性分析.
- 使用接收器操作特征 (ROC) 曲线来识别与AKI风险相关的索引氧气输送值.
- 单独分析了STAT 4-5新生儿和STAT 1-3婴儿的数据.
主要成果:
- 在研究队列中,AKI发生在21.2%的人群中.
- 索引氧气输送值为340毫升/分钟/平方米,预测了STAT 4-5新生儿的AKI (AUC = 0.66).
- 400毫升/分钟/平方米的索引氧气输送值预测了STAT 1-3婴儿的AKI (AUC = 0.65).
结论:
- 在心肺绕道术期间的指数化氧气输送是儿童心脏手术患者与AKI相关的可修改因素.
- 在新生儿中维持指数化氧气输送>340毫升/分钟/平方米,在婴儿中维持指数化氧气输送>400毫升/分钟/平方米可能有助于预防术后的AKI.
- 这些发现表明,针对优化氧气输送的有针对性的策略可以减轻AKI风险.
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