时间效率高,高阻力启发性肌肉力量训练增加中年和老年人的脑血管反应性
Kaitlin A Freeberg1, Daniel H Craighead1, Thomas C Heinbockel1
1Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, United States.
American journal of physiology. Heart and circulatory physiology
|September 8, 2023
概括
高阻力启发性肌肉力量训练 (IMST) 可以改善高血压的老年人脑血管反应能力和情节性记忆. 这种节省时间的训练对增强认知功能和降低痴呆风险有很大希望.
科学领域:
- 神经科学和衰老研究研究
- 心血管健康和大脑功能
- 呼吸系统肌肉训练干预措施 干预措施
背景情况:
- 老龄化增加了痴呆症的风险,部分原因是系统性血压升高 (SBP) 和脑血管功能障碍.
- 高阻力启发性肌肉力量训练 (IMST) 有效降低SBP,并改善老年人的血管功能.
- IMST对脑血管功能的影响及其潜在机制在很大程度上仍未被探索.
研究的目的:
- 调查IMST是否增强中年/年长的中年/老年人正常以上SBP的脑血管对高头症 (CVR到CO2) 的反应.
- 为了确定IMST是否会改变影响大脑内皮细胞功能的血因素.
- 评估IMST对认知表现的影响,特别是情节性记忆.
主要方法:
- 一项为期6周的双盲随机对照试验,比较高抗性IMST (75%PImax) 与低抗性的假干预.
- 参与者包括中年/老年人 (50-79岁),最初的SBP高于正常水平.
- 测量包括参与者血暴露的人类大脑内皮细胞 (HBECs) 中的CVR到CO2,乙胆刺激的氧化 (NO) 生产,以及NIH工具箱认知测试.
主要成果:
- 高电阻的IMST显著增加了对CO2的CVR (P=0.020).
- 来自IMST后参与者的血增强了HBECs中乙胆刺激的NO生产 (P<0.001),表明内皮功能得到改善.
- 插曲记忆在IMST后略有增加 (P=0.045),而假记忆组没有显著变化.
结论:
- 高抗性IMST是一种有希望的,时间效率高的策略,可以改善脑血管反应能力和认知功能,这些人面临认知能力下降的风险.
- 这种干预可以通过对血因子的有益变化来增强大脑内皮细胞的功能.
- IMST提供了一种潜在的非药理学方法来缓解与年龄相关的认知衰退和与高血压相关的痴呆风险.
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