中脑动脉脉动率与年龄相关的增加在男性和女性之间有所不同
Wesley K Lefferts1, Krista S Reed1, Rachel E Rosonke1
1Department of Kinesiology, Iowa State University, Ames, Iowa, United States.
American journal of physiology. Heart and circulatory physiology
|September 8, 2023
概括
与男性相比,女性与年龄相比,脑脉动和动脉硬度的增加更快,特别是在中年. 这种加速的脉动性可能有助于大脑衰老中的性别差异.
科学领域:
- 心血管生理学心血管生理学
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
背景情况:
- 大脑衰老中的性别差异尚未完全理解,但可能涉及到大脑脉动性血流.
- 与衰老相关的动脉硬化和脉压增加可能会影响大脑的血液流动和健康.
研究的目的:
- 为了研究与大动脉硬,动脉脉压和大脑脉动性相关的年龄变化中的性别差异.
- 检查不同年龄组和性别的动脉硬,脉冲压和大脑脉动性之间的关系.
主要方法:
- 对206名男性和217名女性的横截面分析,年龄在18-72岁之间.
- 测量了大动脉硬度 (带-大腿脉冲波速),带脉冲压,带β-硬度和中脑动脉脉动率指数.
- 采用了度,超声波和横多普勒测试,对共变量进行调整后进行回归分析.
主要成果:
- 对于大多数血管指标,发现了显著的年龄性相互作用.
- 与男性相比,女性表现出主动脉硬度的缓慢增加,但随着年龄的增长,动脉硬度和脉冲压的增加更大.
- 妇女中脑动脉脉动的加速增加,这与大脑动脉脉压有关.
结论:
- 与男性相比,女性在中年期中脑脉动能力的增加不成比例.
- 过度增加的动脉硬度和女性的脉压力可能会导致大脑脉加速.
- 这些发现表明,潜在的血管机制有助于大脑衰老中的性别差异.
相关概念视频
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
15
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
15
01:24Blood Pressure
3.2K
The movement of blood in a human body, commonly referred to as blood flow, is determined by the volume of blood that traverses a certain section of the bodily system per unit time. It is the rhythmic contraction of the heart's ventricles that primarily instigates this movement. As the ventricles contract, blood is forced into the prominent arteries, which then flow from areas of greater pressure to lower pressure areas. This movement continues into smaller arteries and arterioles and...
3.2K