在艾滋病毒感染者和艾滋病毒阴性个体中冠状动脉内皮功能和衰老
Efthymios Ziogos1,2, Yaa A Kwapong1, Robert G Weiss2,3
1Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
American journal of physiology. Heart and circulatory physiology
|September 8, 2023
概括
在没有艾滋病毒的人群中,冠状动脉内皮功能随着年龄的增长而下降,但在艾滋病毒感染者 (PWH) 中却没有下降. 这表明其他因素会影响PWH患者一生中冠状动脉疾病的风险.
科学领域:
- 心血管疾病 心血管疾病
- 传染病免疫学 传染病免疫学
- 医疗成像医学成像
背景情况:
- 冠状动脉疾病 (CAD) 是人类免疫缺陷病毒 (HIV) 感染者的重要并发症.
- 冠状动脉内皮功能障碍 (CEF) 是CAD发展的关键因素.
- 艾滋病毒感染者 (PWH) 的衰老与CEF之间的关系尚不清楚.
研究的目的:
- 研究与没有艾滋病毒的个人相比,PWH中年龄和CEF之间的关联.
- 在两种人群中表征CEF与年龄相关的变化.
主要方法:
- 使用3-T磁共振成像 (MRI) 来评估CEF.
- 测量冠状动脉横截面积 (CSA) 和冠状动脉血流在等比手握运动 (IHE) 期间的变化作为内皮依赖的压力因素.
- 包括研究中的106名PWH和82名没有艾滋病毒的人.
主要成果:
- 与没有艾滋病毒的个人相比,PWH中CEF显著较低.
- 在PWH中,冠状动脉内皮功能障碍在较年轻的年龄被观察到.
- 在没有艾滋病毒的人群中,CEF与年龄相反相关;然而,在PWH中没有发现CEF和年龄之间的显著关联.
结论:
- 与年龄相关的CEF下降在没有艾滋病毒的人群中存在,但在PWH中没有.
- 除了年龄之外的其他因素在整个生命周期内显著损害了PWH中的CEF.
- 这项研究是第一个使用MRI探索PWH中年龄-CEF关系的研究.
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