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Updated: Jul 17, 2025

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
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基于机制的GAP重新设计以激活瘤性RAS

Dénes Berta1, Sascha Gehrke1, Kinga Nyíri2,3

  • 1Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT, United Kingdom.

Journal of the American Chemical Society
|September 8, 2023
PubMed
概括

但突变会导致癌症. 这项研究揭示了GTP水解机制,并设计了新的Ras-GAP突变物来恢复瘤性Ras蛋白的功能.

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