冠状神经系统:矿物质皮质体受体和帕奇科罗伊德受体之间的联系
Bastien Leclercq1, Allon Weiner2, Marta Zola1,3,4
1Centre de Recherche des Cordeliers, Inserm, Université Paris Cité, Sorbonne Université, Physiopathology of Ocular Diseases: Therapeutic Innovations, 15 rue de l'Ecole de Médecine, 75006, Paris, France.
Acta neuropathologica
|September 8, 2023
概括
矿物质皮质类受体 (MR) 的过度激活会导致胆管神经病变,解释了胆管神经病变谱和中央血清胆管蛋白病变 (CSCR). 这种神经免疫交叉连接将葡萄糖皮质类药物与患者的帕奇科罗伊德连接起来.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
背景情况:
- 中央血清性胆色素变异症 (CSCR) 与帕奇科罗伊德谱和葡萄糖皮质激素使用有关.
- 葡萄糖皮质类药物激活矿物质皮质类受体 (MR),它们的过度激活在视网膜和胸膜中具有病原性.
- MR 信号的作用和其对冠状神经系统 (ChNS) 的影响仍然未被探索.
研究的目的:
- 调查MR信号在帕奇科罗伊德和CSCR病变发生过程中的作用.
- 为了描述整个胆道血管系统的ChNS内化.
- 为了探索神经免疫交叉通话在状腺.
主要方法:
- 在动物和人类中对ChNS的解剖神经化学表征.
- 对过度表达人类MR的转基因小鼠进行超结构分析.
- 在转基因小鼠中对RPE/choroid复合物的转录基因分析.
主要成果:
- 整个冠状动脉系统 (动脉,静脉,冠状动脉) 是由中枢神经系统内置的.
- 转基因小鼠中的MR过度激活会诱导一种类似于帕奇科罗伊德的表型,带有胆管神经病变.
- 转录组分析显示,皮质体基因向基因的变异表达涉及神经病理生理学,血管系统发育,缺氧,亡和炎症.
结论:
- MR过度激活会导致胆管神经病变,这可能解释了胆管神经表型.
- 在患有dysautonomia的患者中,MR诱导的胆管神经病变可能会将葡萄糖皮质类药物与帕奇科罗伊德和CSCR联系起来.
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