初级Sjögren综合征与肠道微生物群破坏之间的关联:系统性审查和元分析
Yue Shen1, Xue Yu1, Qiao Wang2
1The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
与健康对照人群相比,初级Sjögren综合征 (pSS) 患者的肠道微生物群多样性减少. 这种失生症涉及亲炎性细菌的增加和有益的抗炎微生物的减少,这表明PSS在病变发生过程中发挥了作用.
科学领域:
- 微生物组研究的研究.
- 自免疫性疾病的发病因子自免疫性疾病的发病因子.
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群的破坏与各种自身免疫性疾病有关.
- 肠道微生物群在原发性Sjögren病 (pSS) 中的特定作用需要进行系统的研究.
研究的目的:
- 通过元分析系统地阐明肠道微生物群与原发性Sjögren病之间的关系.
- 在pSS患者和健康对照中量化评估α-多样性,并定性分析β-多样性和微生物丰富度.
主要方法:
- 进行了对9个数据库的系统搜索,以查找与pSS患者和健康对照 (HCs) 进行比较的病例控制研究.
- 数据从开始到2023年3月1日被分析,重点是α-多样性,β-多样性和相对微生物丰富度.
- 包含915名pSS患者和2103名HC患者的22项研究被纳入了元分析.
主要成果:
- 与HC相比,在pSS患者中观察到α-多样性 (Shannon-Wiener,Chao1,ACE指数) 的显著减少.
- 在pSS患者和HC患者之间,β多样性显著不同,这表明了不同的微生物社区结构.
- 关键的发现包括Firmicutes的丰富性下降,Proteobacteria的丰富性增加,以及Ruminococcaceae和Lachnospiraceae等短链脂肪酸 (SCFA) 生产细菌的枯竭.
结论:
- 肠道微生物群失调,其特点是减少多样性和改变微生物组成,与原发性Sjögren病有关.
- 在pSS患者中,促炎细菌的丰富和抗炎细菌的枯竭表明了对疾病发病的贡献.
- 需要进一步的研究,以充分了解肠道微生物群在pSS中的作用及其作为治疗点的潜力.
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