大洋洲多发性硬化症 (MS) 的流行,系统性审查和元分析
Abdorreza Naser Moghadasi1, Narges Ebrahimi2,3, Elahe Haghparast4
1Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
概括
大洋洲的多发性硬化症 (MS) 患病率随着时间的推移显著增加. 这一系统性审查和元分析强调了整个地区MS病例的急剧增加.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 大洋洲是一个庞大的大陆,拥有超过4400万居民,呈现出不同报告的多发性硬化症 (MS) 患病率.
- 了解大洋洲MS的流行病情景对于公共卫生规划和资源分配至关重要.
研究的目的:
- 进行系统性审查和元分析,以估计大洋洲多发性硬化症 (MS) 的综合流行率.
- 分析该地区不同时期的多发性硬化症流行趋势.
主要方法:
- 在包括PubMed,Scopus,EMBASE,Web of Science和Google Scholar在内的主要科学数据库中进行了全面的文献搜索.
- 数据提取包括研究特征,参与者人口统计,疾病细节和流行率. 两个独立的研究人员进行了搜索和数据提取.
- 在对38000多份记录进行严格选后,最终的系统综述和元分析包括了17项研究.
主要成果:
- 在大洋洲,MS的综合流行率在1961年估计为每10万人中19.85 (I2=70.3%,p=0.001).
- 到1981年,大洋洲的多发性硬化综合患病率增加到每10万人的39.07 (I2=88%,p=0.001).
- 分析表明,在研究的时间段内,多发性硬化症的流行率大幅增加.
结论:
- 多发性硬化症 (MS) 的患病率在大洋洲随着时间的推移显著增加.
- 这些发现凸显了该地区越来越多的MS负担,以及对促成因素的进一步调查的需要.
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