参与奥斯特霍尔神经保护作用的信号通路:证据和机制
Lovedeep Singh1,2, Rajbir Bhatti3
1Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, 143005, Punjab, India. lovedeep.e13279@cumail.in.
Molecular neurobiology
|September 8, 2023
概括
传统中医药中的Osthole是一种化合物,通过调节关键细胞信号通路,表现出神经保护作用. 本次审查强调了其在治疗神经退行性疾病方面的潜力,通过促进神经元的存活和功能.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 分子生物学分子生物学
背景情况:
- 神经退行性疾病涉及渐进的神经元损失和突触可塑性异常.
- 异常细胞信号级联是神经退行开始和进展的核心.
- 现有的治疗方法有限,需要针对分子途径的新型治疗策略.
研究的目的:
- 审查和综合涉及到孔介导神经保护的分子信号通路.
- 探索 Osthole 作为神经退行性疾病治疗剂的潜力.
- 阐明奥斯霍尔对神经发生,突触可塑性和神经元存活的影响背后的机制.
主要方法:
- 系统的文献审查来自PubMed,Scopus,Science Direct和Web of Science的32篇文章.
- 整合和讨论已发表的关于信号媒介的孔调制的报告.
- 使用文献证据构建 Osthole 的生物合成途径.
主要成果:
- Osthole通过刺激Notch,BDNF/TrkB和PI3K/Akt通路来促进神经发生和神经元功能.
- 它对神经保护蛋白 (BDNF,TrkB,CREB,Nrf-2,PI3K,Akt) 进行上调,并激活Wnt信号传递.
- 奥斯霍尔通过MAPK/NF-κB和NLRP-3炎症酶途径抑制神经炎症,减少氧化应激和tau病理.
结论:
- 奥斯霍尔通过多个信号通路表现出显著的神经保护作用,包括Notch,BDNF/TrkB,PI3K/Akt和Wnt.
- 它调节酶活性,炎症和氧化应激的能力将其定位为有前途的治疗候选者.
- 需要进一步的临床研究来探索osthole在治疗神经退行性疾病方面的潜力.
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