在BRCA1/2载体中RRSO后患子宫内膜癌的风险:一个多中心队列研究
Helena Pla-Juher1,2,3, Marta Pardo4, Àngel J Izquierdo4,5,6
1Medical Oncology, Catalan Institute of Oncology, Hospital Universitari Dr. Josep Trueta, Avinguda de França s/n, 17707, Girona, Spain. hpla@iconcologia.net.
概括
患有BRCA1/2突变,接受降低风险的卵巢切除术 (RRSO) 的女性没有患子宫内膜癌 (EC) 的风险增加. 对于这些BRCA携带者来说,不建议在RRSO后进行子宫切除术.
科学领域:
- 妇科瘤学 妇科瘤学
- 癌症遗传学 癌症遗传学
- 预防医学 预防医学
背景情况:
- BRCA1/2致病变体显著增加卵巢和乳腺癌的风险.
- 降低风险的卵管切除术 (RRSO) 是管理这些风险的常见策略.
- 在BRCA携带者中,RRSO对随后的子宫内膜癌 (EC) 风险的影响尚未完全理解.
研究的目的:
- 为了评估患有BRCA1/2致病或可能致病变体的妇女的子宫内膜癌 (EC) 发病率,在经历了降低风险的salpingo-oophorectomy (RRSO) 后.
主要方法:
- 分析了在西班牙加泰罗尼亚四家医院 (1999-2019) 接受RRSO的857名BRCA突变女性的队列.
- 基于区域癌症注册数据计算了EC的标准化发病率 (SIR).
- 该研究将观察到的EC病例与一般人群中预期的病例进行了比较.
主要成果:
- 在研究队列中,在RRSO后发现了8例EC (4个BRCA1,4个BRCA2载体).
- 观察到的EC病例数量与预期的3.67个EC病例数量进行了比较.
- 标准化发病率 (SIR) 计算为2.18 (95% CI:0.93-3.95),表明没有统计学上显著的风险增加.
结论:
- 在该队列中,RRSO后的BRCA1/2携带者中,子宫内膜癌 (EC) 的发病率没有超过预期.
- 对于BRCA1/2携带者,仅仅基于RRSO后的突变状态,不建议进行例行切除子宫.
- 这些发现有助于针对BRCA突变携带者的个性化风险管理策略.
关键词:
这就是BRCA BRCA.乳腺癌是什么? 乳腺癌是什么这种癌症叫做carcinosarcoma.这是子宫内膜癌的癌症.胚胎内膜腺癌 (Endometrioid carcinoma) 是一个癌症.切除子宫切除术 (hysterectomy) 是一个切除子宫切除术.突变突变是一种突变.降低风险的盐卵巢切除术可以减少风险.血清性癌细胞瘤是什么塔莫西芬 (Tamoxifen) 是一种更多相关视频
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