对于免疫相关不良事件的NLR和PLR的预测价值:系统性审查和元分析
Hong-Rui Lu1,2, Peng-Fei Zhu1,2, Ya-Ya Deng2,3
1Graduate School of Clinical Medicine, Bengbu Medical College, Bengbu, 233000, Anhui Province, China.
概括
低中性粒细胞-淋巴细胞比率 (L-NLR) 和低血小板-淋巴细胞比率 (L-PLR) 是接受免疫检查点抑制剂 (ICI) 的癌症患者免疫相关不良事件 (irAEs) 的显著预测因素. 这些发现表明,对高风险患者进行更密切的监测.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物标志物 生物标志物
背景情况:
- 免疫检查点抑制剂 (ICI) 是关键的癌症疗法,但它们的使用可能导致与免疫相关的不良事件 (irAEs).
- 需要可访问和负担得起的生物标志物来预测接受ICI治疗的癌症患者的irAEs.
- 这项研究调查了中性粒细胞-淋巴细胞比率 (NLR) 和血小板-淋巴细胞比率 (PLR) 对irAEs的预测值.
结论:
- 低NLR和低PLR都是ICI治疗的癌症患者中irAEs的显著预测因素.
- 这些比率为风险分层提供了有价值,易于使用的工具.
- 被确定为具有高风险的irAEs患者需要更密切的监测和警观察.
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