早期儿童的SARS-CoV-2感染和小岛自身免疫的发展
Marija Lugar1, Anne Eugster1, Peter Achenbach2,3,4
1Technische Universität Dresden, Center for Regenerative Therapies Dresden, Dresden, Germany.
JAMA
|September 8, 2023
概括
患有1型糖尿病遗传风险的婴儿感染COVID-19与小岛自身免疫有关. 接触SARS-CoV-2增加了发展小岛自身抗体的风险,这是1型糖尿病的前体.
科学领域:
- 儿童内分泌学
- 病毒学
- 免疫学
背景情况:
- 在COVID-19大流行期间,儿童糖尿病发病率上升.
- 了解SARS-CoV-2与小岛自身免疫之间的联系对于预测儿童糖尿病趋势至关重要.
研究的目的:
- 调查SARS-CoV-2感染和幼儿时群岛自身免疫的发展之间的时间关联.
- 评估高危婴儿感染SARS-CoV-2后小岛自身抗体的发生风险.
主要方法:
- 主要口服胰岛素试验招募了1050名患有1型糖尿病的基因风险高的婴儿.
- 通过抗体发育识别了SARS-CoV-2感染;通过随访监测到2岁的小岛自身抗体.
- 与SARS-CoV-2暴露相关的岛屿自身抗体的发生率和危险比率进行了分析.
主要成果:
- 在170名儿童中开发出SARS-CoV-2抗体;在60名儿童中开发出小岛自身抗体.
- 患有SARS-CoV-2抗体的儿童患小岛自身抗体的风险增加了3.5倍 (HR,3.5;95%CI,1.6-7.7).
- 在18个月前发生的SARS-CoV-2感染的风险更高 (HR,5.3;95% CI,1.5-18.3).
结论:
- 在基因易患1型糖尿病的婴儿中,SARS-CoV-2感染与小岛自身免疫性暂时相关.
- 这种关联表明SARS-CoV-2在儿童1型糖尿病的病因中可能发挥作用.
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