同时使用COVID-19和流感疫苗的免疫性和反应性
Tal Gonen1,2, Noam Barda1,3,4,5, Keren Asraf6
1Sheba Pandemic Research Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
JAMA network open
|September 8, 2023
概括
与单独接种疫苗相比,COVID-19和流感疫苗的同时使用显示出类似的安全性和免疫反应. 这支持将两种疫苗结合起来,以更好地遵守和公共卫生.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 季节性流感和COVID-19疫苗通常是分开使用的.
- 同时使用可以改善接种疫苗的坚持.
- 关于COVID-19和流感联合疫苗的安全性和有效性的数据有限.
研究的目的:
- 为了比较联合使用的COVID-19和流感疫苗与单独接种COVID-19疫苗的反应性和免疫性.
- 评估两种疫苗同时使用时的安全性和免疫反应.
主要方法:
- 一项涉及以色列医疗保健工作者的前性队列研究.
- 参与者要么单独接种COVID-19疫苗,要么单独接种流感疫苗,要么同时接种两种疫苗.
- 通过数字问卷评估反应性;通过抗尖峰IgG标位测量免疫性.
主要成果:
- 与单独接种COVID-19疫苗相比,同时服用疫苗并没有显著增加系统性症状的风险 (OR,0.82;95%CI,0.43-1.56).
- 抗尖峰IgG的几何平均标位在联合管理组略低 (0.84倍于单独COVID-19组),但在类似的范围内 (95%CI,0.69-1.04).
- 该研究包括588名参与者进行反应性分析和151名参与者进行免疫性分析.
结论:
- 同时使用COVID-19和流感疫苗是安全的,没有显著增加的不良事件.
- 与流感疫苗同时使用,对COVID-19疫苗接种的免疫反应不会显著受到影响.
- 研究结果支持这些疫苗的联合使用,以提高疫苗接种率和公共健康.
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