从109 695个基于实体瘤组织的综合基因组资料中获得临床意义的见解
Andreas M Heilmann1, Jonathan W Riess2, Margaret McLaughlin-Drubin1
1Foundation Medicine, Cambridge, MA, USA.
The oncologist
|September 8, 2023
概括
基金会OneCDx瘤分析在约一半患有固体瘤的患者中发现了临床显著的基因组变化. 这些发现为癌症治疗决策和临床试验资格提供了宝贵的见解.
科学领域:
- 基因组医学是一种基因组医学.
- 在瘤学瘤学.
- 分子诊断学 分子诊断学
背景情况:
- FoundationOneCDx是美国和日本批准的伴随诊断测试.
- 它确定了有资格接受30种 (美国) 和23种 (日本) 药物治疗的患者.
- 除了伴随诊断之外,它还检测出临床上重要的基因组发现,用于更广泛的护理决策.
研究的目的:
- 报告从 FoundationOneCDx 实体瘤档案中获得的临床决策见解的广度和影响.
- 分析综合基因组分析在常规临床护理中的实用性.
主要方法:
- 对109,695个连续的FoundationOneCDx固体瘤测试报告进行了回顾性分析.
- 鉴定临床显著的预测性,预后性和诊断性基因组变化和签名.
- 根据可采取行动,调查或假设的目标,将瘤形状与干预性临床试验相匹配.
主要成果:
- 临床显著的预测,预后和诊断标记在51.2%的所有瘤形状中被报告.
- 观察到泛癌预测标志物,如高瘤突变负担 (TMB) 和微卫星不稳定性 (MSI).
- 89.2%的个人资料具有基因组结果,可能为免疫疗法和向治疗临床试验选择提供信息.
结论:
- 大约有一半具有固体瘤形状的患者显示出临床显著的基因组发现.
- 基金会OneCDx为现实世界癌症患者护理提供了有价值的基因组见解.
- 这些发现支持在常规瘤实践中使用全面的基因组分析.
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