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Updated: Jul 17, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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通过分子对接和分子动力学研究,重新利用批准的药物向CDK4/6和芳酶蛋白

Fatima A Yousif1, Abdulrahim A Alzain1, Alhafez M Alraih2

  • 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Madani, Sudan.

PloS one
|September 8, 2023
PubMed
概括

这项研究通过计算选12,432种化合物来确定ER+乳腺癌的潜在多向药物. 阿波莫尔芬对CDK4/6和芳酶表现出最有前途的结合亲和力,这表明它作为一种新型治疗剂的潜力.

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