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Updated: Jul 17, 2025

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对于POLE3介导的DNA双链断裂修复的WDR70的要求

Xiaobing Mao1, Jian Wu1, Qin Zhang1

  • 1Department of Biotherapy, Cancer Center and State Laboratory of Biotherapy, and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.

Science advances
|September 8, 2023
PubMed
概括

通过与RNF20/40.的相互作用,WDR70促进了组素修饰H2BK120ub1. 这一过程与POLE3和CHRAC1一起,对于DNA修复和保持基因组稳定性至关重要,为癌症提供潜在的治疗点.

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