认知不灵活性与强迫症障碍中异常的前端对象相关激活和连接性有关
Qian Liu1,2,3,4,5,6,7, Feng Gao1,2,3, Xiang Wang1,2,3
1Medical Psychological Center, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Human brain mapping
|September 8, 2023
概括
患有强迫症 (OCD) 的患者由于大脑连接的改变而表现出认知不灵活性. 这项研究显示,在任务切换过程中,强迫症患者的右上头顶皮层激活和前头头顶皮层网络/默认模式网络超连接性增加.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 精神病学是一个精神病学.
背景情况:
- 强迫症 (OCD) 与认知不灵活性有关,但其神经支仍然不清楚.
- 了解认知不灵活性的神经机制对于开发强迫症向治疗至关重要.
研究的目的:
- 研究与强迫症患者认知不灵活相关的神经基质和功能连接.
- 在强迫症患者和健康对照者之间切换任务时比较认知表现和大脑活动.
主要方法:
- 功能性磁共振成像 (fMRI) 用于在42名强迫症患者和48名健康对照 (HCs) 的指令任务切换范式期间收集大脑活动数据.
- 分析了行为数据,包括反应时间和准确性.
- 心理生理学相互作用 (PPI) 分析探讨了功能连接,皮尔森相关性检查了临床症状,行为和神经活动之间的关系.
主要成果:
- 与强迫症患者相比,强迫症患者的切换成本更高,反应时间较慢,这表明认知灵活性受损.
- 在强迫症组中,fMRI显示在任务切换期间,右上侧顶层皮质 (rSPL) 的激活增加.
- 强迫症患者在前端对象网络 (FPN) 内以及在FPN和默认模式网络 (DMN) 之间显示出功能连接性增加.
- 在强迫症患者中,较高的强迫性得分与更好的开关精度和减少rSPL激活相关.
结论:
- 强迫症患者表现出认知不灵活性,其特点是谨慎的反应策略和神经处理的改变.
- 强迫症认知不灵活的神经机制可能涉及到增加rSPL激活和异常连接在FPN内以及FPN和DMN之间.
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