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Updated: Jul 17, 2025

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions
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Published on: June 23, 2022

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质子化对上腺素的影响 抑制α-synuclein 71-82 寡合化

Gang Wang1, Lili Zhu1,2, Xiaoxiao Wu1

  • 1Key Laboratory of Exercise and Health Sciences (Ministry of Education), Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, and School of Exercise and Health, Shanghai University of Sport, 399 Changhai Road, Shanghai 200438, China.

The journal of physical chemistry. B
|September 8, 2023
PubMed
概括

在帕金森病模型中,上腺素 (NE) 和它的质子形式 (NE+) 抑制了α-synuclein (αS) 聚合. 这两种形式都降低了αSβ片的含量,并破坏了寡合体的形成,提供了潜在的治疗策略.

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