超传输缺陷的普遍性和持续性不同大小的缺陷在眼睛中与中介性与年龄相关的黄斑退行
Onnisa Nanegrungsunk1,2,3, Giulia Corradetti1,2, Phichayut Phinyo4
1Doheny Imaging Reading Center and Doheny Eye Institute, Pasadena, California.
Retina (Philadelphia, Pa.)
|September 8, 2023
概括
超传播缺陷 (hyperTDs) 在中期与年龄相关的黄斑变性中很常见. 较大的超TD更有可能持续超过两年,表明潜在的疾病进展标志物.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
背景情况:
- 中期与年龄相关的黄斑变性 (AMD) 是视力受损的常见原因之一.
- 超传输缺陷 (hyperTDs) 是最近在AMD中发现的一个特征.
- 了解hyperTD的患病率和持续性对于AMD管理至关重要.
研究的目的:
- 为了确定各种大小的超传播缺陷 (hyperTDs) 在中期与年龄相关的黄斑变性 (AMD) 的患病率.
- 根据大小来评估这些高TD的2年持久率.
- 为了评估hyperTDs作为AMD进展的潜在指标.
主要方法:
- 从中级AMD患者的光学连贯性断层扫描 (OCT) 数据的回顾性分析.
- 在基线和2年随访期间,分析了冠状腺面对面的OCT图像,以检测在基线和2年随访期间的超TD (小,中,大).
- 使用Gwet的系数评估了读者之间的协议,高级调查员进行了裁决.
主要成果:
- 在16.8%的眼睛中 (17.0%的患者) 发现了中级AMD.
- 在随访的高TD病变中,71.1%持续超过2年.
- 持久率因大小而异:大TD的百分之百,中等TD的72.7%,小TD的53.3%.
结论:
- 超传播缺陷在中间的AMD中普遍存在.
- 较大的超TD在2年内表现出明显更高的持久率.
- 超TD大小可能是AMD进展的预测因素.
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