临床医生停止使用克洛扎的原因:一项回顾性队列研究
Sandeep Grover1, Nishtha Chaurasiya, Subho Chakrabarti
1From the Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Journal of clinical psychopharmacology
|September 8, 2023
概括
在5.12%的患者中发生了切断克洛扎宾的情况,主要是由于血液失分,不良粘附或镇静. 然而,克洛沙平在这些患者中一半的患者中成功地恢复了治疗,这表明其有可能继续使用.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 关于发展中国家的克洛扎止药率的数据有限.
- 克洛扎是治疗耐药精神分裂症的关键药物.
研究的目的:
- 为了确定临床医生停止使用克洛札的发生率.
- 确定停止克洛扎治疗的主要原因.
- 为了评估克洛札的使用率和成功率,在停止治疗后重新尝试.
主要方法:
- 对859名开始使用克洛扎的患者的治疗记录的回顾性审查.
- 对停止使用克洛沙的原因的分析.
- 检查克洛扎的治疗记录重新挑战.
主要成果:
- 在5.12%的患者 (44/859) 中断了克洛扎平的治疗.
- 停药的主要原因:血液失调 (12),不良粘附 (9),和镇静 (7).
- 在50%的患者中重新开始使用克洛扎宾;成功的再试剂率因最初的停药原因而异.
结论:
- 临床医生停止使用克洛扎宾的比例相对较低 (5.14%).
- 血,粘附问题和镇静是停止使用克洛扎的关键原因.
- 重复使用克洛扎是可行的,并且通常是成功的,即使在最初的停用后.
更多相关视频
05:52Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
15.0K
07:31Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
Published on: May 15, 2020
7.1K
相关概念视频
01:26Psychosis: Goals of Pharmacotherapy
165
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
165
01:29Psychological and Sociocultural Causes of Schizophrenia
107
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
107
02:20Longitudinal Research
12.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.0K
01:28Drug Therapy
68
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
68
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
147
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
147
01:21Antipsychotic Drugs: Typical and Atypical Agents
244
Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
244