需要优先关注的典型有机二 (di-OPEs) 的审查:形成,发生,毒理学和流行病学研究
Yi Peng1, Chongli Shi1, Chen Wang1
1Institute of Environmental pollution and health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
Journal of hazardous materials
|September 8, 2023
概括
有机酸二聚 (di-OPEs),有机酸三聚 (tri-OPEs) 的代谢物,对环境和人类健康构成风险. 本次审查强调了需要进一步研究以改进风险评估的关键di-OPEs.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 生态毒理学 生态毒理学
背景情况:
- 有机酸乙 (OPEs) 广泛使用,其主要代谢产物是有机酸乙 (di-OPEs).
- 虽然有机酸盐试剂 (tri-OPEs) 被广泛研究,但二-OPEs的环境发生,毒性和健康风险仍未得到充分研究.
- 了解di-OPEs对于评估OPE在环境中的整体风险至关重要.
研究的目的:
- 审查三OPEs到二OPEs的代谢.
- 总结二-OPE的环境发生和毒性.
- 为未来的研究和风险评估确定关键的di-OPEs.
主要方法:
- 关于代谢途径的文献综述.
- 在环境矩阵和生物体中系统地搜索对di-OPEs的研究.
- 对已确定的二OPE的毒理和流行病学数据的分类.
主要成果:
- 确定了需要优先研究的六种典型的di-OPE:di-n-butyl酸盐 (DNBP),bis(2-butoxyethyl) 酸盐 (BBOEP),bis(1,3-dichloro-2-propyl) 酸盐 (BDCIPP),bis(2-chloroethyl) 酸盐 (BCEP),bis(1-chloro-2-propyl) 酸盐 (BCIPP) 和二酸盐 (DPHP).
- 该审查综合了有关这些化合物的发生和毒性的当前知识.
- 突出了这些二倍OPE的毒理和流行病学概况中的数据缺口.
结论:
- 二-OPE是来自三-OPE的重要环境污染物.
- 对已识别的六个di-OPE进行优先研究对于准确的风险评估至关重要.
- 这一审查为旨在加强环境OPE风险预警系统的未来研究提供了基础.
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