混乱:在人类癌症中出现的治疗性瘤基因
Shadia Hamoud Alshahrani1, Nodir Rakhimov2, Arti Rana3
1Medical Surgical Nursing Department, King Khalid University, Khamis Mushate, Saudi Arabia.
Pathology, research and practice
|September 8, 2023
概括
分解蛋白 (DVL) 通过增强细胞入侵,存活和转移来促进癌症的进展. 升高的DVL水平可以作为诊断和预后生物标志物,并在各种癌症中介导化学抵抗.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 癌症的特点是无法控制的细胞增殖和转移.
- Wnt信号通路在癌症的发展和进展中起着至关重要的作用.
- 分解 (DVL) 是正规和非正规Wnt信号通路中的关键调节器.
研究的目的:
- 研究DVL在癌症发病过程中的作用背后的分子机制.
- 探索DVL作为癌症诊断和预后生物标志物的潜力.
- 检查DVL参与调解常见癌症治疗药物的化学抵抗.
主要方法:
- 在癌细胞系和临床样本中分析DVL表达水平.
- 调查DVL对癌细胞行为 (如入侵,迁移和亡) 的功能影响.
- 癌症患者的DVL表达和临床病理特征之间的相关性分析.
- 评估DVL在甲索,帕克利塔克塞尔和5-甲的化学抗药性中的作用.
主要成果:
- 在各种癌症类型中观察到DVL表达的增加,与侵略性的临床病理特征相关.
- 发现DVL促进细胞入侵,迁移,增殖,存活,干性和上皮-介质酶过渡 (EMT),同时抑制细胞亡.
- 较高的DVL水平与淋巴结转移,晚期瘤等级和特定组织学类型有关.
- DVL在调解甲酸盐,帕克利塔克塞尔和5-甲的化学抗药性方面发挥了作用.
结论:
- 大发性肺炎表现出致癌性质,驱动癌症进展和转移的关键方面.
- 大发红细胞瘤代表了癌症诊断和预后的有前途的生物标志物.
- 向DVL可能提供一种治疗策略,以克服癌症治疗中的化疗抵抗.
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