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毒素菌与宿主miRNA之间的相互作用:机制和后果

Ahmed S Doghish¹, Mohamed A Ali², Mahmoud A Elrebehy³

¹Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11231, Egypt.

Pathology, research and practice

|September 8, 2023

概括

毒素菌引起的毒素菌会破坏微RNAs (miRNAs). 失调的miRNA配置文件提供了对疾病机制的洞察力以及对毒素菌的潜在诊断工具.

科学领域:

寄生虫学的寄生虫学
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

毒素菌是一种广泛传播的动物性疾病,由*Toxoplasma gondii*引起.
在免疫能力强的个体中,感染可能无症状,潜伏囊,但在免疫能力低下的个体和新生儿中可能导致严重并发症,包括眼睛疾病,死胎和流产.
微RNAs (miRNAs) 是关键的调节分子,在T. gondii*感染期间,它们的配置被破坏.

研究的目的:

审查miRNAs在*Toxoplasma gondii*病变发生中的作用.
探索miRNAs在诊断和确定毒素菌的预后方面的潜在临床应用.

主要方法:

对调查miRNA参与T. gondii*感染的研究的文献综述.
在感染期间由miRNAs调节的信号通路的分析.
检查miRNAs当前和潜在的诊断和预后应用.

主要成果:

*T. gondii*感染显著改变循环中的miRNA配置文件.
这些改变的miRNA配置文件与寄生虫的生存和疾病的发病有关.
调节失调的miRNAs可能可以区分急性和慢性毒素菌,并提供有关疾病机制的见解.

结论:

miRNAs通过调节信号通路,在毒素菌的病变发生过程中发挥着重要作用.
改变的miRNA配置文件对毒素菌的临床诊断和预后有希望.
对基于miRNA的诊断方法的进一步研究可能会改善这种普遍存在的动物性传染病患者的治疗结果.

关键词:

传染性疾病是传染性疾病.诊断诊断诊断诊断诊断这就是米RNA.预测预后预测预测信号通道的信号通道.这种毒性淋巴细胞 (Toxoplasma gondii) 是

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