孕妇使用阿片类药物1997-2016年:一项丹麦药物使用研究
Nete Lundager Klokker Rausgaard1, Anne Broe2, Mette Bliddal3
1Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark.
European journal of obstetrics, gynecology, and reproductive biology
|September 8, 2023
概括
怀孕期间阿片类药物的使用情况保持稳定,可代因的使用量下降,特拉马多尔的处方量增加. 持续的阿片类药物使用者显示剂量增加,突出了怀孕期间需要专注护理的需要.
科学领域:
- 药物监督 药物监督 药物监督
- 生殖健康 生殖健康
- 公共卫生 公共卫生
背景情况:
- 在怀孕期间使用阿片类药物引起了重大关注.
- 关于丹麦特定的阿片类药物处方模式的数据有限.
- 了解这些模式对于孕产妇和胎儿的健康至关重要.
研究的目的:
- 确定丹麦孕妇的阿片类药物处方趋势.
- 从1997年到2016年,分析阿片类药物使用的变化.
- 为了确定与怀孕期间阿片类药物使用相关的因素.
主要方法:
- 在1997-2016年的数据中,利用了全国性的丹麦健康登记册.
- 将阿片类药物分为四组:一般阿片类药物,依赖药物,咳抑制剂和可代因.
- 使用后勤回归和累积口服吗啡等价物 (OMEQ) 进行分析.
主要成果:
- 总体而言,阿片类药物的使用是稳定的 (19.8/1000例怀孕);在2008年后,可代因的使用减少,而其他阿片类药物,特别是特拉马多尔,增加了三倍.
- 处方模式在活产,非活产和终止之间是一致的.
- 吸食阿片类药物与较低的社会经济地位,更高的母亲年龄,肥胖和吸烟有关;持续使用者显示OMEQ增加.
结论:
- 在怀孕期间的阿片类药物使用在2007-2016年间稳定,标志着从可代因向特拉马多尔的转变.
- 虽然更少的女性在整个怀孕期间继续服用阿片类药物,但那些继续服用阿片类药物的女性的OMEQ更高.
- 丹麦的医疗保健服务需要加强对阿片类药物管理的孕前和产前关注.
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