神经外分泌:一种新的类型的腺体在线虫?
Natalia M Biserova1, Ivan A Kutyrev2, Vadim R Saitov3
1Lomonosov Moscow State University, Faculty of Biology, Department of Invertebrate Zoology, Moscow 119234, Russia; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russia.
概括
科学家们发现神经外分泌物在骨中分泌,在那里,专门的神经末会将物质释放到骨上. 这一发现揭示了宿主-寄生虫相互作用和这些分泌物的潜在功能.
科学领域:
- 寄生虫学的寄生虫学
- 神经生物学 神经生物学 神经生物学
- 细胞生物学 细胞生物学
背景情况:
- 通过神经细胞向宿主组织分泌的外分泌物以前在 cestodes 中是未知的.
- 在不同阶层的五种cestode物种中,研究了专门的神经末.
研究的目的:
- 为了研究神经外分泌物在 cestodes 的现象.
- 描述特殊神经末的超结构及其分泌过程.
- 探索神经外分泌在宿主-寄生虫相互作用中的潜在目标和功能.
主要方法:
- 在使用超薄切片的骨干体内,对特殊的"杯状"自由神经末端进行超结构分析.
- 观察子体神经元中的神经分泌过程及其与体末端的连接.
- 在宿主血清中化骨组织,以研究神经分泌细胞和结尾的动态变化.
- 免疫细胞化学方法研究特定的参与.
主要成果:
- 在五种类物种的体中发现了具有神经分泌囊的特殊"杯状"神经末.
- 观察到子体神经分泌过程和外周神经末端之间的直接关系.
- 在宿主血清化期间,神经末端直径,囊泡数量和颗粒大小的变化被观察到,在物种之间有所不同.
- 神经分泌的潜在目标包括腺管道,肌肉和体膜的基底膜.
- 有证据表明,FMRFamide类相关 (FaRPs) 参与了这种神经外分泌分泌.
结论:
- 这项研究证实了神经外分泌物存在于骨中,通过专门的神经末进行介导.
- 观察到的超结构特征和动态变化表明这些神经末的功能分泌作用.
- 神经外分泌物可能在宿主-寄生虫相互作用中发挥作用,可能涉及FaRP.
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