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Updated: Jul 16, 2025

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选择性降解BRD4抑制肺癌细胞增殖使用GSH响应的PROTAC前体

Heli Fan1, Zhili Zhou2, Dehao Yu1

  • 1Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin 300070, PR China.

Bioorganic chemistry
|September 8, 2023
PubMed
概括

研究人员开发了新的对谷氨反应的蛋白解向化体 (PROTACs),以选择性地降解癌细胞中的BRD4. 这种方法尽量减少对正常细胞的毒性,增强向癌症治疗的临床潜力.

关键词:
这是一种抗瘤药物.在 BRD4 降解下降.在GSH-响应的响应.肺癌是一种肺癌.在 Protac 中使用 Protac.

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