通过血脑屏障的荷尔蒙关门控制的种姓特异性行为
Linyang Ju1, Karl M Glastad2, Lihong Sheng2
1Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
血液-大脑屏障 (BBB) 作为幼年激素 (JH3) 的守护者, 调节的社会行为. 在BBB中操纵雌激素 (Jhe) 会重新编程种之间的行为.
科学领域:
- 神经科学
- 内分泌学
- 动物的行为
背景情况:
- 血脑屏障对于保护大脑至关重要.
- 荷尔蒙在调节行为方面发挥着重要作用.
- 昆虫的社会行为是复杂的,受各种因素的影响.
研究的目的:
- 调查BBB在调节社会行为的作用.
- 通过BBB确定荷尔蒙运输的分子机制.
- 探索青少年激素雌激素 (Jhe) 在社会行为调节中的作用.
主要方法:
- 单细胞RNA测序 (scRNA-seq) 用于确定基因定位.
- 在和Drosophila中的Jhe水平的基因操纵.
- 评估社会互动的行为测试.
- 不同基因表达的研究.
主要成果:
- 青春激素酶 (Jhe) 位于的BBB中,控制青春激素 (JH3) 进入大脑.
- 这种操纵会改变大脑的转录组, 重编程种之间的行为.
- 在BBB中,Jhe具有细胞内功能,而Drosophila Jhe则具有细胞外功能.
- 在Drosophila BBB中表达Jhe会改变的行为.
结论:
- BBB 作为神经激素通路的分子守护者.
- 这种BBB功能对于调节复杂的社会行为至关重要.
- BBB在激素调节中的作用可能在各个物种中保持.
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