大型抑郁症与亚临床甲状腺功能障碍并发症的静止状态大脑活动的改变:区域同质性分析
Shuai Zhao1, Jindan Wu2, Xiaomei Liu2
1Department of Psychiatry, the Affiliated Psychological Hospital of Anhui Medical University, Hefei, China; Hefei Fourth People's Hospital, Hefei, China; Anhui Mental Health Center, Hefei, China; Anhui Clinical Research Center for Mental Disorders, China; Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China.
严重抑郁症 (MDD) 与亚临床甲状腺功能低下症 (SHypo) 显示出不同的大脑活动模式. 这项研究揭示了前额叶和叶中独特的神经机制,为共患疾病提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 内分泌学 在内分泌学.
背景情况:
- 大型抑郁症 (MDD) 经常与身体疾病同时发生.
- 在MDD患者中越来越多地观察到亚临床甲状腺功能低下症 (SHypo).
- 共同病变的MDD和SHypo背后的神经机制尚不清楚.
研究的目的:
- 调查共享和独特的大脑功能机制在合并性MDD和SHypo.
- 检查与并发症相关的大脑活动的变化.
- 在并发症患者中确定症状尺寸的神经相关性.
主要方法:
- 使用了休息状态功能磁共振成像 (rs-fMRI).
- 区域同质性 (ReHo) 分析用于评估大脑活动.
- 研究了四组:MDD,并发性MDD+SHypo,SHypo和健康对照.
主要成果:
- 同病组在额叶 (ORBmid,中额叶) 和叶 (中额叶,上额叶) 显示了改变的ReHo.
- 在并发症组的右丘脑和右胰岛中观察到降低的ReHo.
- TSH水平与insula ReHo相关,而ORBmid ReHo与焦虑/体化得分相关.
结论:
- 研究结果表明,共病性MDD和SHypo.的基础上存在着不同的神经机制.
- 这项研究提供了对这种并发性疾病的病理生理学的见解.
- 已确定的大脑区域可以作为未来干预的目标.
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