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Updated: Jul 16, 2025

Highly Sensitive and Quantitative Detection of Proteins and Their Isoforms by Capillary Isoelectric Focusing Method
07:58

Highly Sensitive and Quantitative Detection of Proteins and Their Isoforms by Capillary Isoelectric Focusing Method

Published on: September 19, 2018

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图像化毛细管异电聚焦并列高分辨率质谱学使用纳米电喷射电离 (ESI) 进行蛋白质异质性特征

Teresa Kwok1, She Lin Chan1, Matthew Courtney1

  • 1Advanced Electrophoresis Solutions Ltd., Cambridge, Canada.

Analytical biochemistry
|September 8, 2023
PubMed
概括

一种新的纳米电子喷雾电离 (nano-ESI) 方法直接将成像的毛细血管同电聚焦 (icIEF) 与高分辨率质谱 (HRMS) 结合起来. 这种icIEF-HRMS技术增强了生物治疗电荷异质性分析,以提高药物质量.

关键词:
双特异性抗体 双特异性抗体聚变蛋白质的融合蛋白质是什么图像化毛细血管的异电聚焦.低流电喷射电离化低流电喷射电离化质谱测量质量谱测量单克隆抗体是一种单克隆抗体.纳米电子喷雾电离化电离.蛋白质的异质性 蛋白质的异质性

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