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Updated: Jul 16, 2025

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TFEB调节细胞性铁,并以TfR1依赖的方式预防铁

Leilei Chen1, Yue Ma1, Xizhen Ma1

  • 1Institute of Brain Science and Disease, Qingdao University, Qingdao, Shandong, China; Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Qingdao University, Qingdao, Shandong, China; Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Qingdao University, Qingdao, Shandong, China.

Free radical biology & medicine
|September 8, 2023
PubMed
概括

转录因子EB (TFEB) 的过度表达清除了错误折叠的α-synuclein,并通过通过转激素受体1 (TfR1) 调节铁代谢来预防铁. 这为帕金森病 (PD) 提供了新的神经保护策略.

关键词:
铁化是铁化的一种.铁的代谢 铁的代谢lysosome 是一个溶解体.美国联邦税务法 (TFEB)TfR1 的意思是什么?

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