使用最小和非侵入性抽样方法对内部工作生活暴露组的表征 - - 一个叙述性综述
Eline Verscheure1, Rob Stierum2, Vivi Schlünssen3
1Department of Public Health and Primary Care, Centre for Environment and Health, Katholieke Universiteit Leuven, Leuven, Belgium.
Environmental research
|September 8, 2023
概括
职业暴露组研究在生物样本采集方面面临挑战. 本审查确定了自取样技术作为全面暴露评估的可行解决方案.
科学领域:
- 职业健康 职业健康 职业健康 职业健康
- 环境健康 环境健康
- 生物监测 生物监测
背景情况:
- 传统的"一个暴露,一个疾病"模式正在向职业环境中的终身暴露方法演变.
- 暴露组方法,包括终身总暴露,提出了重大挑战,特别是在生物样本采集.
- 最少侵入性,敏感性和可重复性采样方法对于职业暴露性研究至关重要,特别是在具有挑战性的环境中.
研究的目的:
- 确定现有的生物样本采集自取样技术.
- 评估这些自我采样方法在职业暴露性研究的背景下的适用性.
- 通过解决采样障碍,为设计未来职业暴露研究提供指导.
主要方法:
- 进行了全面的文献审查,以确定和评估当前的自取样方法.
- 审查的重点是适用于表征内部曝光组的技术.
- 生物矩阵的评估是基于入侵性和适合性,用于职业暴露组研究.
主要成果:
- 介绍了当前用于内部曝光体表征的自我采样技术的概述.
- 评估了不同生物矩阵的侵入性和在职业环境中的适用性.
- 自我采样提供了一种潜在的解决方案,以克服职业暴露性研究中的采样困难.
结论:
- 自我采样技术可以有效地解决职业暴露性研究的生物样本采集方面的挑战.
- 这些发现为选择合适的自取样方法和生物矩阵提供了指南.
- 本次审查通过促进强有力的样本采集策略,支持职业暴露研究的进步.
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