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相关概念视频

Preclinical Development: Overview01:28

Preclinical Development: Overview

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Updated: Jul 16, 2025

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography
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基于voxel的分析:临床翻译的路线图

Alan McWilliam1, Giuseppe Palma2, Azadeh Abravan1

  • 1The Division of Cancer Sciences, The University of Manchester, Manchester, UK; The Christie NHS Foundation Trust, Manchester, UK.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
|September 8, 2023
PubMed
概括

在放射治疗中,基于voxel的分析 (VBA) 通过分析完整的3D剂量分布,为剂量-反应关系提供了新的见解. 本路线图指导VBA的临床转化,以改善患者的治疗结果.

关键词:
临床翻译 临床翻译结果建模结果建模.辐射疗法 辐射疗法验证 验证 验证 验证基于Voxel的分析.

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Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
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科学领域:

  • 辐射瘤学 辐射瘤学
  • 医学物理 医学物理
  • 放射治疗研究 放射治疗研究

背景情况:

  • 基于Voxel的分析 (VBA) 能够在放射治疗中全面评估3D剂量分布.
  • 它绕过了对预定义器官的需求,揭示了对解剖学变异性,病理生理学和放射敏感性的洞察.
  • VBA可以揭示整个组织的放射生物异质性和剂量反应关联.

研究的目的:

  • 为基于Voxel的分析 (VBA) 的临床转化提出一个全面的路线图.
  • 概述在临床环境中实施VBA的关键考虑和最佳实践.
  • 促进将VBA发现转化为切实可见的患者益处.

主要方法:

  • 技术验证侧重于方法的稳定性.
  • 临床验证评估对外部数据集的概括性和病理生理学可信性.
  • 临床实用性评估以证明潜在的患者益处.

主要成果:

  • 介绍了VBA临床翻译的结构化路线图.
  • 讨论了技术,临床验证和实用性的关键考虑因素.
  • 每个步骤都提供了最佳实践建议.

结论:

  • 成功的临床转化VBA需要严格的验证和证明患者的好处.
  • 拟议的路线图为在放射治疗中有效实施VBA提供了一个框架.
  • 在推进个性化放射治疗和改善患者治疗结果方面,VBA具有显著的潜力.