婴儿时期母乳养与结肠直肠癌和前体病变的风险
Chen Yuan1, Qiao-Li Wang1, Hanseul Kim2
1Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
概括
婴儿母乳养与成人结直肠癌 (CRC) 的风险更高有关. 这种关联甚至在年轻的成年人中也被观察到,更长的母乳养时间与CRC风险增加有关.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 围产期和生命早期的暴露越来越多地被认为是结直肠癌 (CRC) 发展的因素.
- 婴儿母乳养与成年人CRC风险之间的特定关联,特别是在成年早期,仍然未得到充分研究.
研究的目的:
- 调查婴儿母乳养与患结肠直肠癌 (CRC) 和其前体病变的风险在成年生活中的潜在关联.
- 检查母乳养时间是否影响CRC风险.
- 根据母乳养史,评估年轻成年人的CRC风险.
主要方法:
- 前性队列研究涉及护士健康研究中的66634名女性和护士健康研究II中的92062名女性.
- 利用Cox和后勤回归模型来分析350万人年后续数据.
- 用母乳报告验证了部分参与者的母乳养信息.
主要成果:
- 经过母乳养的病史与23%的CRC风险增加有关.
- 随着母乳养时间的增加 (P < .001),CRC风险呈现出显著的积极趋势 (P < .001).
- 在较年轻的参与者 (≤55岁) 中,母乳养与CRC和高风险腺瘤的更高风险有关.
结论:
- 婴儿母乳养与成人结直肠癌的风险增加有关,包括年轻人.
- 哺乳期的持续时间似乎与CRC风险的大小相关.
- 需要进一步的研究来阐明这种关联背后的生物学机制,因为因果关系尚未确定.
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