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德克斯梅德托米丁通过增强GABAergic突触活性来缓解炎症性疼痛,该活性发生在前环皮质皮质的金字塔神经元中

Ling Liu1, Zhihao Luo2, Yuanying Mai3

  • 1Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China; Department of Anesthesiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China; South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.

Neuropharmacology
|September 8, 2023
PubMed
概括

德克斯梅德托米丁 (DEX) 通过降低前带皮层 (ACC) 金字塔神经元中的过度活动来缓解炎症性疼痛. 这涉及通过Akt路径增强GABAergic抑制,提供一种新的疼痛管理策略.

关键词:
在 ACC ACC ACC ACC ACC ACC ACC ACC ACC ACC ACC德克斯 (DEX) 是一个在GABA(A) R子单元中.炎症性疼痛是一种疼痛.的 p-Akt 行为.

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