从使用FDM技术3D打印的个性化口腔贴片中单向释放药物
1School of Pharmacy, Liaoning University, 66 Chongshan Middle Road, Shenyang 110036, China; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
International journal of pharmaceutics
|September 8, 2023
概括
融化沉积建模 (FDM) 能够创建用于治疗口腔的甲酸口腔贴片. 这些贴片提供单向药物释放,促进愈,而不会引起刺激.
科学领域:
- 药理学 药理学是指药理学的学科.
- 材料科学 材料科学 材料科学
- 药物运输 药物运输 药物运输
背景情况:
- 口腔粘膜药物输送绕过了第一通效应,为治疗口腔疾病提供了有利的途径.
- 口腔的症状和病变大小各不相同,需要量身定制的药物输送系统.
- 德克萨米他酸是一种用于其抗炎性能的皮质类固醇.
研究的目的:
- 开发和描述使用化沉积建模 (FDM) 的单向药物释放口腔贴片.
- 调查保护层厚度和联合挤压印刷对补丁特性的影响.
- 评估为口腔治疗准备的口腔贴片的安全性和有效性.
主要方法:
- 通过FDM制备德克萨米酸口腔贴片,使用乙烯基纤维素进行单向释放和用聚乙烯醇作为载体和塑化剂.
- 优化保护层厚度,并应用与空白丝共挤压印刷,用于各种药物负载.
- 物理化学性质的表征,包括药物释放概况和粘附.
- 在老鼠口腔粘膜刺激的体内评估和愈的药理动力学评估.
主要成果:
- 优化的保护层厚度确保了单向的药物释放.
- 同挤出印刷没有显著影响药物释放或粘附性质.
- 制造的口腔贴片表现出有利的物理化学特征.
- 贴片在老鼠中没有显示出口腔粘膜刺激,并促进了部区域的减少.
结论:
- 化沉积建模 (FDM) 提供了一种实用且高效的方法来制造德甲酸盐口腔贴片.
- 开发的单向药物释放口腔贴片对于促进口腔的愈合是安全有效的.
相关概念视频
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