接种COVID疫苗对每月偏头痛日的影响:一个纵向队列研究
Britt W H van der Arend1,2, Mirthe M Bloemhof1, Alle G van der Schoor1
1Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Cephalalgia : an international journal of headache
|September 8, 2023
概括
在偏头痛患者中,COVID-19疫苗接种增加了每月偏头痛日和头痛日. COVID-19感染增加了急性药物治疗日,但没有显著改变偏头痛或头痛的日子.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 纵向队列研究调查偏头痛的结果.
- 关注COVID-19感染和接种疫苗后的变化.
研究的目的:
- 评估COVID-19感染和疫苗接种对偏头痛频率的影响.
- 分析每月偏头痛日 (MMD),每月头痛日 (MHD) 和每月急性药物治疗日 (MAMD) 的变化.
主要方法:
- 从头痛中心包括59名参与者进行感染分析和147名参与者进行疫苗接种分析.
- 使用头痛电子日记数据和COVID-19暴露和疫苗接种日期的问卷.
- 在感染或接种疫苗前一个月和接种疫苗后一个月的MMD,MHD和MAMD的比较.
主要成果:
- 在接种疫苗后的第一个月内,COVID-19疫苗接种与MMD (1.06天),MHD (1.52天) 和MAMD (0.72天) 的增加相关.
- COVID-19感染与MAMD (1.11天) 的显著增加有关.
- 在COVID-19感染后没有观察到MMD或MHD的统计学意义上的变化.
结论:
- 似乎COVID-19疫苗接种与偏头痛活动的暂时增加有关.
- 研究结果表明,在接种疫苗后,偏头痛病理生理学中,炎症调解者的作用可能很大.
- 需要进一步的研究来了解将COVID-19疫苗接种与偏头痛恶化联系在一起的机制.
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