在疾病中准普罗基尼提辛受体的治疗潜力
Martina Vincenzi1, Amin Kremić1, Appoline Jouve1
1Regenerative Nanomedicine (UMR 1260), INSERM, University of Strasbourg, Center of Research in Biomedicine of Strasbourg, Strasbourg, France (M.V., A.K., A.J., L.D., C.G.N.); Department of Physiology and Pharmacology (M.V., R.L.), and Department of Biochemical Sciences "Alessandro Rossi Fanelli" (R.M.), Sapienza University of Rome, Rome, Italy; University Grenoble Alpes, INSERM, CEA, Grenoble, France (M.B., N.A.); Unité de Biologie Fonctionnelle et Adaptative, Université Paris Cité, CNRS, Paris, France (S.M.); Department of Physiology and Pharamacology, Center for Neurologic Disease Research, University of Georgia, Athens, Georgia (A.G.K.); Department of Biochemistry, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil (M.A.P.); Moores Cancer Center, University of California, San Diego, La Jolla, California (N.F.); and Institute of Structural Biology, Helmholtz Munich - German Research Center for Environmental Health (GmbH), Neuherberg, Germany (I.V.T.); and BIGCHEM GmbH, Valerystr. 49, Unterschleissheim, Germany (I.V.T.).
益生菌素 (PKs) 是调节肠道收缩性的,并参与各种生理途径. 它们的受体 (PKR1和PKR2) 为疾病提供治疗点,非联体显示出有前途.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 分子生物学分子生物学
背景情况:
- 益生菌素 (PKs) 是20年前发现的,最初以诱导肠道收缩性而闻名.
- 现在,PKs被认为是参与血管生成,食欲调节,炎症和神经元功能的多功能信号分子.
- 改变的PK表达或突变与各种疾病有关,表明它们作为生物标志物的潜力.
研究的目的:
- 审查和综合有关 prokineticin (PK) 家族及其受体 (PKR1 和 PKR2) 的当前知识.
- 探索PKs在健康和疾病中的多样化的生理和病理生理作用.
- 在临床前模型中总结PK配体和受体调节剂的治疗潜力.
主要方法:
- 对 prokineticins 和它们的受体进行的研究的文献综述.
- 对内源性和合成PK的作用的数据分析.
- 评估涉及PKR1和PKR2的选择性配体和非调节剂的临床前研究.
主要成果:
- PKs及其受体 (PKR1,PKR2) 在心血管,新陈代谢,神经发育,平衡和疾病中起着关键作用.
- 针对PKR1和PKR2的非类联体在临床前疾病模型中显示出显著的治疗效果.
- 由于它们的表达变化,PKs显示出作为几种疾病的诊断生物标志物的潜力.
结论:
- Prokineticin 系统,包括具有潜在构成性活性的受体,为治疗开发提供了一个有前途的领域.
- 了解PKs及其受体的复杂作用对于开发新型治疗策略至关重要.
- 需要对PK配体及其机制进行进一步的研究,以解决安全问题并优化治疗应用.
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