益生菌对B组链球菌从母亲向新生儿的垂直传播的影响:一项前性开放式随机化研究
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Updated: Jul 16, 2025
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Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
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Yuriha Kasai1, Mitsutaka Komatsu2, Yudai Toyama3
1Department of Pediatric and Adolescent Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan.
Pediatrics and neonatology
|September 8, 2023
概括
在怀孕期间使用Lactobacillus reuteri的益生菌可以减少B组链球菌 (GBS) 传播给新生儿. 虽然这项研究在统计学上并不显著,但它在预防母婴GBS传播方面有潜在的益处.
科学领域:
- 周产期微生物学 周产期微生物学
- 孕产妇和胎儿的健康状况
- 益生菌研究的研究.
背景情况:
- 乙组链球菌 (GBS) 殖民于20-30%的孕妇,构成新生儿感染的风险.
- 益生菌越来越多地研究生产周益处,但它们对GBS母婴传播 (MTCT) 的影响尚不清楚.
研究的目的:
- 调查乳杆菌reuteri补充剂对孕妇B组链球菌 (GBS) 母婴传播 (MTCT) 的影响.
主要方法:
- 涉及GBS阳性培养的孕妇的开放式随机试验.
- 益生菌组从怀孕35-37周到产后1个月接受了Lactobacillus reuteri.
- 新生儿直肠拭子和GBS菌株的全基因组测序被用于评估MTCT.
主要成果:
- 1个月的新生儿GBS阳性是益生菌组的10%,对照组的28%.
- 一个月后GBS MTCT率在益生菌组为6%,在对照组为22%.
- 观察到的差异没有统计学意义 (p=0.0927).
结论:
- 虽然没有统计学意义,但GBS阳性孕妇的Lactobacillus reuteri消费显示出抑制GBSMTCT的趋势.
- 需要进一步的研究来证实益生菌在预防GBS传播方面的潜力.
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