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Updated: Jul 16, 2025

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
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Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Published on: April 1, 2021

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葡萄糖诱导和ChREBP:MLX介导的脂原性计划促进了肝细胞癌的发展

Aijuan Yu1, Pengcheng Yu1,2, Yuwen Zhu1

  • 1Institute of Pediatrics, Children's Hospital of Fudan University, and the Shanghai Key Laboratory of Medical Epigenetics, The International Co-laboratory of Medical Epigenetics and Metabolism, the State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.

Oncogene
|September 8, 2023
PubMed
概括

这项研究揭示了ChREBP:MLX转录因子对于葡萄糖诱导的脂质生成至关重要,驱动肝细胞癌 (HCC) 的发展. 抑制MLX阻断了HCC的进展,突出显示它是肝癌的潜在治疗标.

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Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide07:34

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