创伤性重症儿科患者的预后可以预测吗? :一个多中心的回顾性分析
Ulkem Kocoglu Barlas1, Nihal Akcay2, Mey Talip3
1Istanbul Medeniyet University, Faculty of Medicine, Goztepe Prof Dr Suleyman Yalcin City Hospital, Istanbul, Turkey. ulkemkocoglu@yahoo.com.
Wiener klinische Wochenschrift
|September 8, 2023
概括
中性细胞与淋巴细胞比率 (NLR),单细胞与淋巴细胞比率 (MLR) 和MPV/PC值不能预测儿科创伤的严重程度. 然而,低MLR和高MPV/PC可能预测严重儿科创伤病例的死亡率.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 创伤研究研究创伤研究
- 在儿科的炎症标志物.
背景情况:
- 在重症儿科创伤患者中研究炎症标志物,如中性粒细胞与淋巴细胞的比率 (NLR),单细胞与淋巴细胞的比率 (MLR),MPV/PC,C反应蛋白 (CRP) 和公素 (PCT).
- 评估这些标志物与创伤严重程度或死亡率之间的相关性.
研究的目的:
- 评估NLR,MLR,MPV/PC,CRP和PCT对儿童创伤严重程度和死亡率的预测价值.
- 确定儿童创伤患者风险分层的潜在生物标志物.
主要方法:
- 对80例儿科创伤病例 (31天至16岁) 的回顾性分析,这些病例被送往儿科重症监护室 (PICU).
- 在入院 (T1) 时收集的数据,中位数PICU停留 (T2) 和退院/退院前 (T3).
- 根据伤害严重程度得分 (ISS) 将患者分为轻微,中度和严重的创伤组.
主要成果:
- 死亡率为13.75%. 在美国,死亡率为13.75%. 在创伤严重程度组之间,NLR,MLR,MPV/PC和PCT值没有显著差异.
- 与T1和T2的重创病例相比,中度创伤病例的CRP水平较高.
- 没有幸存者有更高的ISS和PRISM-3分数,以及较低的RISC-II,RISC-II生存率和GCS分数. 在非幸存者中,T3 MLR较低,T3 MPV/PC较高.
结论:
- NLR,MLR和MPV/PC值不是儿童创伤严重程度的可靠预测指标.
- 在T3时低的MLR和高的MPV/PC值可以作为严重创伤的儿科患者死亡率的预测指标.
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