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IL-10基因多态性 (- 1082 A/G, -819 T/C, -592 A/C) 与肝细胞癌之间的关联:一个元分析和试验序列分析

Teresa Tan Yen Mei^1,2, Htar Htar Aung³, Wong Siew Tung¹

¹School of Medicine, International Medical University, Kuala Lumpur, Malaysia.

|September 8, 2023

概括

介素-10 (IL-10) 基因多态性 (-1082 A/G 和 -819 T/C) 显示出与肝细胞癌风险的种族特异性关联. 然而,样本规模不足限制了确的证据,强调了需要进行更大规模的研究.

科学领域:

遗传学遗传学是一个
在瘤学瘤学.
分子生物学分子生物学

背景情况:

肝细胞癌 (HCC) 的发展是复杂的,遗传因素可能会影响肝细胞转化.
针对它们在HCC发育中的作用,已经探索了Interleukin-10 (IL-10) 基因多态性.

研究的目的:

通过全面的元分析,调查IL-10基因多态 (-1082 A/G,-819 T/C,-592 A/C) 与肝细胞癌风险之间的关联.

主要方法:

按照PRISMA 2020指南进行了系统的文献搜索.
在五种遗传模型中,分析了15项病例控制研究 (n=8182),使用组合的几率比率 (OR) 和95%置信区间 (CI).
使用纽卡斯尔-太华尺度标准评估了研究质量,并进行了种族分层和试验顺序分析 (TSA).

主要成果:

在整体异合体模型中观察到IL-10 (-1082 A/G) 和HCC风险之间的边际关联.
对于非亚洲人群中的IL-10 (-1082 A/G) (主导性,异合性,等位基模型) 和非亚洲人群中的IL-10 (-819 T/C) (主导性,衰退性,同合性模型) 发现了显著的关联.
没有发现IL-10 (-592 A/C) 与HCC风险的显著关联;TSA仅证实了这种多形态的足够信息大小.

结论:

IL-10 (-1082 A/G和-819 T/C) 多态表现出与HCC的种族特异性关联,但证据因样本大小不足而受到限制.
IL-10 (-592 A/C) 多态性显示没有与HCC的关联,得到了足够的统计能力的支持.
建议对IL-10 (-1082 A/G和-819 T/C) 多态性进行进一步的大规模,精心设计的跨不同种族的病例控制研究.

关键词:

遗传关联是一种遗传关联.肝细胞癌是肝细胞癌.IL-10 基因多态的多态性试验的顺序分析.这是一个元分析.

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