极度早产婴儿的氧和度和早产视网膜病变 - 一个病例对照研究
Varnika Aggarwal1, Risha Bhatia1,2, Kenneth Tan3,4
1Department of Paediatrics, Monash University, Melbourne, Australia.
BMC pediatrics
|September 8, 2023
概括
这项研究发现,虽然暴露于氧气并没有显著影响早产儿视网膜病变 (ROP) 风险,但新生儿手术是显著的风险因素. 对早产婴儿的ROP发展进行进一步的研究至关重要.
科学领域:
- 新生儿医学 新生儿医学
- 眼科医生 眼科 眼科
- 儿科重症监护 儿科重症监护
背景情况:
- 早产视网膜病变 (ROP) 是早产婴儿视力损伤的重要原因之一.
- 识别ROP的风险因素对于及时干预和预防策略至关重要.
- 氧气暴露是ROP发展的一个已知但复杂的因素.
研究的目的:
- 调查风险因素的关联,包括氧气暴露,在早产婴儿中发展早产视网膜病变 (ROP).
- 分析氧气输送方法,和水平和灵感氧气分数对ROP发生率的影响.
- 确定新生儿手术作为ROP的潜在风险因素的作用.
主要方法:
- 一项病例控制研究将123名患有ROP的婴儿与没有ROP的对照进行了匹配,出生时怀孕28周以下.
- 从电子医疗记录收集临床数据,包括氧气输送,SpO2,FiO2和MAP.
- 使用 MATLAB 的时间平均 SpO2 分析和使用 Stata/SE 16.0.0 的统计分析.
主要成果:
- 与非ROP组相比,ROP组在过氧中花费的时间更长 (p < 0.001).
- 在接受氧气支持 (FiO2 > 21%) 时,在两组之间没有观察到SpO2的显著差异.
- 新生儿手术显著增加了ROP风险 (OR = 1.4347,p = 0.010),而出生体重和氧气暴露的影响是微不足道的.
结论:
- 在呼吸辅助期间,ROP和非ROP组之间的氧气和水平没有差异.
- 新生儿外科手术成为与发展ROP的可能性增加相关的显著风险因素.
- 该研究强调了将手术作为ROP病变发生的风险因素的重要性.
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