多胎妊娠后代的长期结果:使用英国生物银行和FinnGen数据库对多系统疾病进行两样本的门德尔随机化研究
Yi Jiang1, Yuanyuan Du1, Rui Su1
1Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, 430030, Hubei, China.
Journal of translational medicine
|September 8, 2023
概括
多重分娩,通常来自辅助生殖技术 (ART),显示婴儿脑和心血管疾病的风险增加. 然而,它们可能会对一些呼吸系统疾病 (如喘) 提供保护.
科学领域:
- 遗传学和流行病学
- 生殖健康 生殖健康
背景情况:
- 辅助生殖技术 (ART) 有助于增加多胎出生.
- 多重分娩对母亲和后代的健康构成风险.
- 调查多胎和常见疾病之间的联系至关重要.
研究的目的:
- 为了检查遗传预测多胎与42种常见疾病的风险之间的联系.
- 使用遗传数据探索潜在的因果关系.
主要方法:
- 采用了双样本的门德尔随机化 (MR) 分析.
- 用FinnGen和英国生物银行数据集进行遗传分析.
- 研究了对多胎出生和疾病风险的遗传倾向之间的因果关系.
主要成果:
- 在多胎和精神疾病之间没有发现显著的因果关系.
- 多胎出生被确定为婴儿脑的危险因素.
- 在多胎出生和心血管疾病 (如冠心病,深静脉血栓症) 之间观察到潜在的因果关系.
- 多重分娩对某些呼吸道疾病 (例如,慢性肺炎,喘) 有保护作用.
结论:
- 建议小心对婴儿脑和心血管疾病的风险在多胎出生.
- 对抗呼吸道疾病的潜在保护作用需要进一步研究.
- 研究结果可以为预防策略和多胎儿的临床管理提供信息.
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