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PHaLIR:预防循环结节术逆转后 - - 一项随机对照多中心研究的研究方案

Karolina Eklöv¹, Sven Bringman^2,3, Jenny Löfgren⁴

¹Department of Clinical Science and Education, Södersjukhuset, Karolinska Institute, Stockholm, Sweden. karolina.eklov@ki.se.

|September 8, 2023

概括

在口腔关闭后发生 Hernia 是很常见的. 一项研究比较标准关闭与回肌合成网,用于循环静脉切除术逆转,旨在减少发生率和改善外科手术结果.

科学领域:

一般外科整体外科
手术瘤学手术瘤学
胃肠病学胃肠病学

背景情况:

结直肠癌手术通常涉及临时循环结直肠,以后可以逆转.
静脉静脉静脉关闭后,静脉静脉关闭部位的 Hernia 是一个常见的并发症,在7-15%的患者中发生.
目前用于闭口腔的方法,主要是 suturing,没有明确的最佳策略来预防.

研究的目的:

为了比较标准关闭与回肌合成网,用于循环静脉切除术逆转.
为了评估预防性网的有效性,减少关闭后的发生.
评估二次结果,包括手术时间,住院时间,疼痛和并发症.

主要方法:

多中心,双盲,随机对照试验.
患有直肠癌的前下切除术的患者,并计划进行静脉切除术逆转.
1:1随机化到标准合闭合或回肌合成网状闭合.

主要成果:

这项研究旨在检测发生率从12%降至3%的逆肌网.
术后3年内在静脉位发生是主要结局.
在30天的随访中对患者,图表和观察员的手术方法进行盲目评估.

结论:

这项研究将提供证据,证明背肌肉合成网的有效性,防止循环静脉关闭后的.
积极的发现可能会导致对静脉栓逆转手术的最新手术指南.
这项研究解决了直肠癌手术中的重大并发症,旨在改善患者的治疗结果.

关键词:

Hernia 这是一个.循环静脉切除术逆转防止的发生.这是直肠癌.

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