患有慢性炎症性肠道病变的狗的血清和便中的3-甲氨酸度:临床参数和组织病理变化
Panpicha Sattasathuchana1, Naris Thengchaisri1, Yasushi Minamoto2
1Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
Animals : an open access journal from MDPI
|September 9, 2023
概括
在患有慢性炎症性肠道病变 (CIEs) 的狗中,血清和便中的3 - 铁素 (3-BrY) 度升高. 然而,3-BrY水平可能不准确地反映了CIE狗的胃肠炎症的严重程度.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 胃肠病学 胃肠病学
- 生物标志物发现发现
背景情况:
- 慢性炎症性肠道病变 (CIEs) 在狗中很常见,其特征是胃肠组织炎症.
- 需要准确的诊断和预后标志物用于犬类CIE.
- 3-甲基 (3-BrY) 是一种潜在的炎症生物标志物.
研究的目的:
- 为了评估血清和便中的3 - 米洛辛 (3-BrY) 度的敏感性,在狗中使用CIE.
- 评估3-BrY度是否与患有CIE的狗中胃肠道病理变化的严重程度相关.
主要方法:
- 68只被诊断患有CIE的狗被纳入.
- 血清和便样本被分析为3-BrY度.
- 测量了血清C反应蛋白 (CRP) 和便α1-蛋白酶抑制剂.
- 评估了与犬慢性肠病临床活动指数的相关性.
主要成果:
- 在CIE的90.9%的狗中发现血清3-BrY升高.
- 在75.8%和69.4%的狗中分别发现了便3-BrY (平均值和最大值) 的升高.
- 在血清CRP和血清3-BrY之间观察到较弱的相关性.
- 在3-BrY度和临床活性指数或肠道病理的严重程度之间没有发现显著的相关性.
结论:
- 患有CIE的狗表现出血清和便中的3-BrY度增加.
- 作为CIE存在的生物标志物,3-BrY显示出高灵敏度.
- 3-BrY度可能不是狗CIE炎症严重程度的可靠指标.
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